Ganciclovir

Generic for Zirgan

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What is ganciclovir?

Ganciclovir is a prescription antiviral ophthalmic gel used to treat acute herpetic keratitis—corneal ulcers and dendritic lesions caused by herpes simplex virus in the eye. Unlike many eye drops, it's formulated as a gel that stays in contact with the ocular surface longer, providing sustained antiviral drug delivery with each application. Ganciclovir works by blocking viral DNA polymerase, preventing the herpes virus from replicating within infected corneal cells. It's applied five times daily until the ulcer heals, then three times daily for an additional week, and is the only antiviral gel approved for this indication in the United States.

Viral DNA polymerase inhibition

Ganciclovir is phosphorylated by viral kinase inside HSV-infected cells and then blocks viral DNA polymerase — halting viral DNA replication and preventing the spread of herpes simplex virus through corneal tissue.

Gel formulation for sustained ocular contact

Unlike aqueous eye drops that drain quickly from the eye surface, ganciclovir's gel vehicle maintains prolonged contact with the cornea — improving drug residence time and antiviral exposure at the site of infection.

Corneal ulcer healing support

By suppressing viral replication in infected corneal epithelium, ganciclovir stops the active herpetic lesion from expanding and allows corneal epithelial cells to heal — reducing the risk of vision-threatening corneal scarring from recurrent herpetic keratitis.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

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I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

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