Fosfomycin

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What is Fosfomycin?

Fosfomycin is an oral antibiotic prescribed to treat uncomplicated urinary tract infections in women, taken as a single 3-gram powder packet dissolved in water. Its standout feature is its convenience—one dose is the entire treatment course. Fosfomycin works by blocking a key step in bacterial cell wall synthesis, killing the bacteria responsible for the UTI. It's particularly useful for treating UTIs caused by bacteria that have become resistant to other antibiotics, including some strains of E. coli and Enterococcus faecalis. Symptom improvement is typically felt within 2–3 days.

Cell wall synthesis inhibition

Blocks MurA enzyme—an early and essential step in bacterial peptidoglycan cell wall construction—preventing bacteria from building and maintaining the structural wall they need to survive and replicate.

Single-dose treatment

The entire antibiotic course is one packet mixed in water and taken once, eliminating the multi-day compliance challenge of standard UTI antibiotic regimens—with no doses to forget or skip.

Resistance-active coverage

Fosfomycin's unique mechanism of action means it retains activity against many antibiotic-resistant UTI pathogens, including some ESBL-producing E. coli strains that have become resistant to commonly used oral antibiotics.

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