Fluoxetine

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What is Fluoxetine?

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) and one of the most widely recognized antidepressants in the world. It's approved for major depressive disorder, OCD, bulimia nervosa, panic disorder, bipolar depression (in combination), and premenstrual dysphoric disorder. Fluoxetine has the longest half-life of any SSRI—5–6 days—which makes it the most forgiving if a dose is missed and allows for easier discontinuation without the withdrawal symptoms that can accompany shorter-acting SSRIs. It's taken once daily, often in the morning due to its mildly activating nature.

Serotonin reuptake inhibition

Blocks the serotonin transporter, increasing serotonin availability in the synaptic space to regulate mood, reduce anxiety, and improve emotional stability across depression, OCD, and related conditions.

Longest SSRI half-life

With a half-life of 5–6 days (and an active metabolite lasting even longer), Fluoxetine is uniquely forgiving of missed doses and produces minimal discontinuation symptoms—an important practical advantage for patients who struggle with consistent adherence.

Multi-condition approval

One of the few SSRIs approved for bulimia nervosa, with evidence for reducing binge-purge episodes alongside its established efficacy for depression, OCD, panic disorder, and PMDD—offering broad coverage across comorbid psychiatric presentations.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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—Kaylee, Louisiana

“I couldn't be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

—Nika, Tennessee

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