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Fluconazole (Diflucan)
Virtual visit

Fluconazole (Diflucan)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Fluconazole (Diflucan) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Fluconazole (Diflucan)?

Fluconazole is an oral antifungal medication used to treat a wide range of fungal infections including vaginal yeast infections, oral thrush, esophageal candidiasis, and systemic fungal infections. It works by blocking an enzyme essential to the synthesis of ergosterol—a critical component of the fungal cell membrane—causing the membrane to become leaky and the fungus to die. For vaginal yeast infections, a single 150mg dose is often all that's needed. For more serious or recurrent infections, a longer course is prescribed.

Ergosterol synthesis blockade

Inhibits the fungal enzyme CYP51, preventing the conversion of lanosterol to ergosterol—a sterol essential to the integrity and function of the fungal cell membrane—leading to membrane disruption and fungal cell death.

Broad fungal coverage

Effective against Candida species responsible for most yeast infections as well as Cryptococcus and other pathogens, making it useful across a spectrum of fungal infections from superficial to systemic.

Single-dose convenience for yeast infections

One oral 150mg tablet is clinically proven to treat uncomplicated vaginal yeast infections—eliminating the need for multi-day topical creams and providing systemic coverage that reaches the infection from within.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

Is one dose really enough for a yeast infection?

For uncomplicated vaginal yeast infections, a single 150mg oral dose is clinically proven to be effective for most people. For recurrent or severe infections, longer courses of multiple doses may be prescribed.

How quickly will my yeast infection symptoms improve?

Most people experience symptom relief within 24 hours, with full resolution typically occurring within 3–7 days of the single dose. If symptoms persist beyond a week, contact your clinician for reevaluation.

Can men take fluconazole for a yeast infection?

Yes. Fluconazole is used to treat penile yeast infections (balanitis) and other candida infections in men. The dose and duration depend on the location and severity of the infection.

What side effects might I experience?

Headache, nausea, abdominal pain, and diarrhea are most common and usually mild. Fluconazole interacts with several medications — particularly blood thinners and certain statins — so a medication review is important before use.

Can I take fluconazole during pregnancy?

Caution is advised. High-dose or repeated fluconazole use during pregnancy has been associated with birth defects. A single low dose may sometimes be used, but always discuss with your clinician first.
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