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Estradiol (Estrace)
Virtual visit

Estradiol (Estrace)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Estradiol (Estrace) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Estradiol (Estrace)?

Estrace is an oral estrogen medication containing estradiol—the primary form of estrogen produced by the ovaries—used to treat menopausal symptoms including hot flashes, night sweats, vaginal dryness, and mood changes. It's also used in hormone therapy for transgender women and in cases of premature ovarian insufficiency. Taken as a daily tablet, it restores estrogen levels that decline during and after menopause. For women with a uterus, a progestin is typically prescribed alongside it to protect the uterine lining from overstimulation.

Estrogen receptor activation

Binds to estrogen receptors throughout the body—in the brain, bones, cardiovascular system, and genitourinary tract—restoring the hormonal signaling that declines with menopause and drives its wide range of symptoms.

Hot flash and vasomotor relief

Directly addresses the hypothalamic thermoregulatory instability caused by estrogen deficiency, reducing the frequency and severity of hot flashes and night sweats that disrupt daily life and sleep.

Genitourinary and bone health

Restores vaginal tissue health, reduces urinary symptoms associated with genitourinary syndrome of menopause, and helps maintain bone density—protecting against the accelerated bone loss that follows estrogen decline after menopause.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How is oral Estrace different from the estradiol patch?

Estrace is swallowed daily and processed through the liver before reaching the bloodstream — which can affect certain proteins and clotting factors. The patch delivers estradiol directly through the skin, bypassing the liver entirely.

Do I need a progestin alongside Estrace?

If you have a uterus, yes. Estrogen therapy without a progestin increases the risk of uterine lining overgrowth and endometrial cancer. Your clinician will prescribe a progestin to take alongside Estrace.

How long before Estrace relieves hot flashes?

Many people notice improvement in hot flashes and night sweats within the first 2–4 weeks of consistent daily use. Full symptom relief typically develops over 4–8 weeks at an effective dose.

What side effects might I experience?

Breast tenderness, bloating, nausea, headache, and mood changes are most commonly reported. These often improve after the first 2–3 months as hormone levels stabilize. Irregular spotting can occur initially.

Is Estrace the same as bioidentical estrogen?

Yes. Estradiol (the active ingredient in Estrace) is bioidentical — meaning it has the same molecular structure as the estrogen your body naturally produces. It differs from conjugated equine estrogens found in some other HRT products.
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