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Epiduo (Benzoyl peroxide - adapalene)
Virtual visit

Epiduo (Benzoyl peroxide - adapalene)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Epiduo (Benzoyl peroxide - adapalene) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Epiduo?

Epiduo is a prescription topical gel combining adapalene, a retinoid, with benzoyl peroxide to treat acne. It addresses multiple factors that contribute to acne simultaneously—clogged pores, excess oil, and acne-causing bacteria—in a single once-daily application. Adapalene normalizes the skin cell turnover process that leads to clogged follicles, while benzoyl peroxide kills Cutibacterium acnes (the bacteria that drive inflammatory breakouts) and reduces excess sebum. The combination is more effective than either ingredient alone and is approved for use in patients aged 9 and older.

Retinoid-mediated pore clearance

Adapalene binds to nuclear retinoic acid receptors, normalizing follicular keratinization—the skin cell shedding process that, when disrupted, leads to clogged pores and comedone formation.

Antibacterial oxidative action

Benzoyl peroxide generates reactive oxygen species that kill Cutibacterium acnes within the follicle, reducing the bacterial load that triggers the inflammatory response behind papules and pustules.

Combination synergy

Adapalene and benzoyl peroxide work through completely different mechanisms and target different aspects of acne pathogenesis—their combination is clinically superior to either alone and less prone to driving antibiotic resistance than antibiotic-based acne treatments.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How long does it take Epiduo to clear acne?

Meaningful improvement in inflammatory acne — fewer pimples and pustules — is typically seen within 8–12 weeks of once-daily use. Full results continue developing over 3–6 months of consistent treatment.

Why does my skin seem worse in the first few weeks?

An initial purging phase — where existing congestion is pushed to the surface faster — is common with retinoid-containing treatments like Epiduo. This is a normal adjustment that typically passes within 4–6 weeks.

Should I use Epiduo in the morning or at night?

Epiduo can be used at either time, though evening application is commonly recommended since adapalene increases sun sensitivity. If applied in the morning, daily broad-spectrum sunscreen use is essential.

What side effects might I experience?

Dryness, peeling, redness, and stinging — particularly in the first few weeks — are very common as skin adjusts. Starting with every-other-day application and gradually increasing frequency can help minimize early irritation.

Can I use moisturizer with Epiduo?

Yes — and it's recommended. A non-comedogenic moisturizer helps manage the dryness and irritation that often accompany retinoid and benzoyl peroxide use. Apply it after Epiduo has fully absorbed into the skin.
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