Epiduo

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Available nationwide

What is Epiduo?

Epiduo is a prescription topical gel combining adapalene, a retinoid, with benzoyl peroxide to treat acne. It addresses multiple factors that contribute to acne simultaneously—clogged pores, excess oil, and acne-causing bacteria—in a single once-daily application. Adapalene normalizes the skin cell turnover process that leads to clogged follicles, while benzoyl peroxide kills Cutibacterium acnes (the bacteria that drive inflammatory breakouts) and reduces excess sebum. The combination is more effective than either ingredient alone and is approved for use in patients aged 9 and older.

Retinoid-mediated pore clearance

Adapalene binds to nuclear retinoic acid receptors, normalizing follicular keratinization—the skin cell shedding process that, when disrupted, leads to clogged pores and comedone formation.

Antibacterial oxidative action

Benzoyl peroxide generates reactive oxygen species that kill Cutibacterium acnes within the follicle, reducing the bacterial load that triggers the inflammatory response behind papules and pustules.

Combination synergy

Adapalene and benzoyl peroxide work through completely different mechanisms and target different aspects of acne pathogenesis—their combination is clinically superior to either alone and less prone to driving antibiotic resistance than antibiotic-based acne treatments.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

Thousands of customers trust us

“I feel like I'm finally on the right path to improving my health with the right support now! It's so refreshing and reassuring.”

—Emerald, Texas

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

—Kaylee, Louisiana

“I couldn't be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

—Nika, Tennessee

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Frequently asked questions

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General Medicine provides convenient care for all of your of health needs, including common and chronic conditions, specialist consultations, and preventative care. We make it easy to get the care you need—whether it's getting the right prescriptions, labs or imaging, or connecting you with the right specialists or in-person providers—ensuring your healthcare experience is seamless and stress-free.

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