Emgality

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Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Emgality?

Emgality is a CGRP monoclonal antibody injection used for the preventive treatment of migraine in adults and for the treatment of episodic cluster headache. It works by binding to and blocking calcitonin gene-related peptide (CGRP), a neuropeptide that is central to the initiation of migraine and cluster headache attacks. By neutralizing CGRP before it can trigger pain signaling, Emgality reduces both the frequency and severity of attacks over time. For migraine prevention, it's injected once monthly; for cluster headache, a higher loading dose is given at the start of a cluster period.

CGRP ligand neutralization

Binds directly to the CGRP molecule—rather than its receptor—preventing it from triggering the trigeminal inflammatory cascade that initiates migraine and cluster headache pain.

Migraine and cluster headache coverage

One of the few treatments approved for both episodic migraine prevention and episodic cluster headache—a severe, poorly-treated headache disorder where treatment options have historically been very limited.

Once-monthly preventive dosing

A single monthly subcutaneous injection provides continuous CGRP neutralization and sustained reduction in attack frequency—significantly simpler than daily oral preventive medications and with effects maintained as long as treatment continues.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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