Efudex

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What is Efudex?

Efudex is a prescription topical chemotherapy cream containing 5-fluorouracil (5-FU), used to treat actinic keratoses—precancerous skin lesions caused by chronic sun damage—and certain superficial skin cancers. It works by interfering with DNA synthesis in rapidly dividing cells, selectively destroying abnormal, sun-damaged cells while leaving healthy surrounding skin intact. Treatment causes a predictable inflammatory reaction—redness, peeling, crusting—that signals the medication is working. Applied once or twice daily for 2–4 weeks, it's a non-surgical way to treat widespread precancerous lesions across large skin areas.

Pyrimidine antimetabolite action

5-Fluorouracil is incorporated into cellular DNA and RNA in place of uracil, blocking thymidylate synthase and preventing DNA replication—selectively targeting the rapidly dividing abnormal cells of actinic keratoses while relatively sparing normal skin.

Field treatment advantage

Unlike cryotherapy that treats individual lesions one at a time, Efudex applied to a large area treats both visible lesions and subclinical sun-damaged cells not yet visible to the eye—providing comprehensive field clearance of precancerous changes.

Inflammatory reaction as treatment signal

The expected redness, erosion, and crusting during treatment indicates that abnormal cells are being destroyed—this reaction is a sign the treatment is working, and resolution of inflammation marks the successful clearance of treated tissue.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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