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Edarbyclor (Azilsartan - chlorthalidone)
Virtual visit

Edarbyclor (Azilsartan - chlorthalidone)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Edarbyclor (Azilsartan - chlorthalidone) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Edarbyclor (Azilsartan - chlorthalidone)?

Edarbyclor is a combination blood pressure medication pairing azilsartan, an angiotensin II receptor blocker (ARB), with chlorthalidone, a long-acting thiazide-like diuretic. Together, they lower blood pressure through two distinct and complementary mechanisms—blocking vasoconstriction from angiotensin II and reducing fluid volume through increased kidney excretion. Combining an ARB with a diuretic is a well-established approach to achieving greater blood pressure reduction than either drug alone, making Edarbyclor appropriate for patients who need more aggressive hypertension control in a single daily pill.

Angiotensin II receptor blockade

Azilsartan blocks AT1 receptors, preventing angiotensin II from causing vasoconstriction and fluid retention—directly relaxing blood vessels and reducing peripheral resistance.

Diuretic volume reduction

Chlorthalidone is a long-acting diuretic that reduces blood pressure by decreasing circulating fluid volume—its extended half-life provides more consistent 24-hour blood pressure control than shorter-acting thiazide diuretics.

Complementary dual-class efficacy

Combining an ARB and a diuretic addresses both the vascular tone and the fluid volume components of hypertension simultaneously—producing additive blood pressure reduction that exceeds what either class achieves alone.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

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Frequently Asked Questions

Why were two blood pressure medications combined in one pill?

Combining an ARB and a diuretic in a single tablet simplifies the regimen, reduces pill burden, and improves long-term adherence compared to managing two separate prescriptions — a meaningful benefit for chronic blood pressure management.

How is chlorthalidone different from hydrochlorothiazide (HCTZ)?

Chlorthalidone is longer-acting than HCTZ — providing more consistent 24-hour blood pressure control with less fluctuation. Some data suggest it may also reduce cardiovascular events more effectively than HCTZ.

How long before Edarbyclor reaches full blood pressure effect?

Blood pressure reduction typically begins within the first week. Full effect at a given dose develops over 2–4 weeks. Your clinician may adjust the dose after adequate time to assess your response.

What side effects might I experience?

Dizziness — particularly when standing quickly — low potassium, elevated uric acid (which can trigger gout), increased urination, and muscle cramps are the most commonly reported effects with this combination.

Can I take Edarbyclor during pregnancy?

No. Azilsartan — the ARB component — is contraindicated in pregnancy and can cause serious fetal harm. Stop taking it immediately and contact your clinician if pregnancy occurs while on Edarbyclor.
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