Doxepin

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Available nationwide

What is Doxepin?

Doxepin is a tricyclic antidepressant that, at higher doses, treats depression and anxiety, and at very low doses is FDA-approved specifically for insomnia characterized by difficulty staying asleep. Its sleep-promoting effects come from its potent antihistamine activity, which produces sedation without the dependency risks of traditional sleep medications. At the low doses used for insomnia (3–6 mg), it's one of the few medications approved for sleep maintenance insomnia—the frustrating pattern of waking up in the middle of the night or too early in the morning.

Histamine H1 receptor blockade

At low doses, Doxepin's powerful antihistamine action produces robust sedation by blocking H1 receptors in the brain, extending sleep duration without the tolerance, dependence, or next-day impairment of many other sleep medications.

Sleep maintenance focus

Uniquely approved for sleep maintenance insomnia (difficulty staying asleep), rather than just sleep onset—addressing the middle-of-night and early morning awakening patterns that many patients struggle with most.

Non-controlled sleep option

Not a controlled substance at any dose, meaning it can be prescribed more freely and used longer-term without the regulatory restrictions and dependency concerns that apply to benzodiazepines and Z-drugs.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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—Kaylee, Louisiana

“I couldn't be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

—Nika, Tennessee

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General Medicine provides convenient care for all of your of health needs, including common and chronic conditions, specialist consultations, and preventative care. We make it easy to get the care you need—whether it's getting the right prescriptions, labs or imaging, or connecting you with the right specialists or in-person providers—ensuring your healthcare experience is seamless and stress-free.

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