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Depo-SubQ Provera 104® (Depo-SubQ Provera 104)

With decades of use in gynecological care, Depo-SubQ Provera 104 is a progestin prescribed for a range of hormonal needs, from period regulation to protecting the uterus during hormone therapy. After you book, your clinician reviews your history so your visit is about finding the right fit for you, whether that's Depo-SubQ Provera 104 or another option.

Used to regulate periods, trigger a withdrawal bleed, or protect the uterus during HRT

Can be taken continuously or cyclically depending on the treatment goal

Available as a generic (Depo-SubQ Provera 104) at low cost

Visit options

We'll check any insurance and show you your options before you book.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Depo-SubQ Provera 104?

Depo-SubQ Provera 104 is a synthetic progestin used to treat a range of hormonal conditions including abnormal uterine bleeding, secondary amenorrhea (absent periods), and endometriosis. It's also used alongside estrogen therapy in postmenopausal women to protect the uterine lining from overgrowth. Depo-SubQ Provera 104 mimics the natural progesterone your body produces, helping regulate the menstrual cycle and maintain the health of the uterine lining. Depending on the condition being treated, it may be taken continuously or cyclically for a set number of days each month.

Progestogenic uterine regulation

Mimics natural progesterone to stabilize and regulate the uterine lining—preventing the unchecked endometrial growth that causes irregular or heavy bleeding and protecting against uterine hyperplasia.

Cycle restoration

For women with absent or irregular periods due to hormonal imbalance, Depo-SubQ Provera 104 can be used to trigger a withdrawal bleed, effectively resetting the menstrual cycle and confirming hormonal responsiveness.

Hormone therapy balance

When used alongside estrogen in menopausal hormone therapy, Depo-SubQ Provera 104 counteracts estrogen's stimulating effect on the uterine lining, significantly reducing the risk of endometrial cancer.

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently asked questions

What conditions is Depo-SubQ Provera 104 used for?

Depo-SubQ Provera 104 is prescribed for absent or irregular periods, abnormal uterine bleeding, endometriosis, and to protect the uterine lining when estrogen therapy is used after menopause. The dose and schedule depend on the indication.

How long before Depo-SubQ Provera 104 brings on a period?

When used to trigger a withdrawal bleed in women with absent periods, Depo-SubQ Provera 104 is typically taken for 5–10 days. Bleeding usually occurs within a few days of completing the course.

Can I take Depo-SubQ Provera 104 during pregnancy?

No. Depo-SubQ Provera 104 is contraindicated during pregnancy. If there is any possibility of pregnancy before starting Depo-SubQ Provera 104, a pregnancy test should be completed first. Inform your clinician immediately if pregnancy is suspected.

What side effects might I experience?

Headache, breast tenderness, bloating, mood changes, and irregular spotting are among the most commonly reported side effects. Weight changes and depressed mood can also occur in some people.

Is Depo-SubQ Provera 104 the same as Depo-Provera?

No. Depo-SubQ Provera 104 is an oral tablet taken daily for short courses. Depo-Provera is an injectable contraceptive given every three months. They contain the same active ingredient (Depo-SubQ Provera 104) but differ significantly in formulation, dose, and purpose.