Daraprim

Brand for pyrimethamine

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What is Daraprim?

Daraprim is a prescription antiparasitic medication used to treat toxoplasmosis — a serious infection caused by the parasite Toxoplasma gondii — typically in combination with a sulfonamide antibiotic. It's particularly critical for immunocompromised people, including those with HIV/AIDS, organ transplant recipients, and pregnant women, in whom toxoplasmosis can cause severe neurological disease. Daraprim works by blocking an enzyme the parasite needs to produce folate, which is essential for its DNA synthesis and replication. Because it also affects human folate metabolism, leucovorin (folinic acid) is co-administered to prevent bone marrow suppression.

Dihydrofolate reductase inhibition

Selectively blocks the parasite's dihydrofolate reductase enzyme at much lower concentrations than the human equivalent, preventing Toxoplasma gondii from synthesizing the folate needed for DNA replication and cell division.

Combination regimen cornerstone

Used alongside sulfadiazine or clindamycin, which block an earlier step in the same folate synthesis pathway—the combination creates synergistic antiparasitic activity that is far more effective than either drug alone.

Leucovorin co-administration

Daraprim's folate pathway inhibition affects human bone marrow cells as well as the parasite—leucovorin (folinic acid) is given concurrently to bypass this blockade in human cells and prevent the anemia and neutropenia that would otherwise result.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

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Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

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I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

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Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

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Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

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The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

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