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Daraprim (Pyrimethamine)
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Daraprim (Pyrimethamine)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Daraprim (Pyrimethamine) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

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Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

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Available nationwide

What is Daraprim (Pyrimethamine)?

Daraprim is a prescription antiparasitic medication used to treat toxoplasmosis—a serious infection caused by the parasite Toxoplasma gondii—typically in combination with a sulfonamide antibiotic. It's particularly critical for immunocompromised patients, including those with HIV/AIDS, organ transplant recipients, and pregnant women, in whom toxoplasmosis can cause severe neurological disease. Pyrimethamine works by blocking an enzyme the parasite needs to produce folate, which is essential for its DNA synthesis and replication. Because it also affects human folate metabolism, leucovorin (folinic acid) is co-administered to prevent bone marrow suppression.

Dihydrofolate reductase inhibition

Selectively blocks the parasite's dihydrofolate reductase enzyme at much lower concentrations than the human equivalent, preventing Toxoplasma gondii from synthesizing the folate needed for DNA replication and cell division.

Combination regimen cornerstone

Used alongside sulfadiazine or clindamycin, which block an earlier step in the same folate synthesis pathway—the combination creates synergistic antiparasitic activity that is far more effective than either drug alone.

Leucovorin co-administration

Pyrimethamine's folate pathway inhibition affects human bone marrow cells as well as the parasite—leucovorin (folinic acid) is given concurrently to bypass this blockade in human cells and prevent the anemia and neutropenia that would otherwise result.

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Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

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We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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Frequently Asked Questions

What is Daraprim used for?

Daraprim is the primary treatment for toxoplasmosis — a potentially serious parasitic infection particularly dangerous in immunocompromised patients including those with HIV/AIDS, organ transplant recipients, and pregnant women.

Why is Daraprim always prescribed with another medication?

Pyrimethamine alone is not sufficient — it's always combined with a sulfonamide antibiotic (typically sulfadiazine) to block the same folate pathway at two sequential steps, producing synergistic antiparasitic activity.

Why must I take leucovorin (folinic acid) with Daraprim?

Pyrimethamine blocks folate metabolism in both the parasite and human cells. Leucovorin bypasses this blockade in human cells — protecting bone marrow from the anemia and neutropenia that pyrimethamine would otherwise cause without it.

What side effects might I experience?

Bone marrow suppression — causing anemia, low white blood cells, and low platelets — is the most serious risk and monitored through regular blood tests. Nausea, vomiting, and loss of appetite are also commonly reported.

How long does toxoplasmosis treatment typically last?

Acute treatment typically lasts 6 weeks or more. In immunocompromised patients — particularly those with HIV — suppressive maintenance therapy at lower doses may be continued long-term to prevent recurrence.
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