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Cymbalta (Duloxetine)
Virtual visit

Cymbalta (Duloxetine)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Cymbalta (Duloxetine) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Cymbalta (Duloxetine)?

Cymbalta is a serotonin-norepinephrine reuptake inhibitor (SNRI) prescribed for depression, anxiety, chronic pain conditions like fibromyalgia, and nerve pain associated with diabetes. By increasing the availability of two key neurotransmitters—serotonin and norepinephrine—it helps regulate mood, reduce emotional distress, and dampen pain signals in the nervous system. Taken once daily, it typically takes 2–4 weeks before mood improvements are noticed, while pain relief may develop more gradually over several weeks.

Dual neurotransmitter action

Blocks the reabsorption of both serotonin and norepinephrine in the brain, increasing their availability to stabilize mood and reduce anxiety more broadly than SSRIs alone.

Central pain modulation

Norepinephrine plays a key role in how the brain processes pain signals—Cymbalta helps turn down that volume, making it effective for chronic nerve and musculoskeletal pain.

Whole-body benefit

A single medication can simultaneously address depression or anxiety and physical pain symptoms, which often co-occur and reinforce each other in many patients.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How long until Cymbalta starts working?

Mood and anxiety improvements typically begin within 2–4 weeks, though full benefit may take 4–8 weeks. Pain relief for conditions like fibromyalgia follows a similar or slightly longer timeline.

Can I stop taking it whenever I want?

No — Cymbalta should always be tapered gradually under clinician guidance. Stopping abruptly can cause discontinuation symptoms including dizziness, nausea, irritability, and sensations sometimes described as "brain zaps."

Does Cymbalta cause weight gain?

Weight changes vary by person. Some experience modest changes in either direction. Cymbalta is less associated with weight gain than some other antidepressants, but individual responses differ.

What side effects might I experience?

Common side effects include nausea, dry mouth, fatigue, dizziness, and sweating — most pronounced in the first few weeks. Taking it with food helps with nausea. Sexual side effects can also occur.

Can Cymbalta treat both my depression and chronic pain?

Yes — this is one of Cymbalta's most clinically meaningful advantages. It's FDA-approved for both major depression and several chronic pain conditions, allowing a single medication to address both simultaneously.
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