Comprehensive fatigue panel
Persistent tiredness with no single clear cause calls for checking several possibilities at once rather than one at a time. This panel checks nutrient levels, thyroid function, infection markers, and other blood health indicators together.
Reviewed by a licensed clinician, with follow-up if anything's out of range
Fasting is required
Biotin supplements can affect this result — hold off taking them for 2 to 3 days before your test
Most insurance accepted
Board-certified clinicians
No hidden fees
Available nationwide
What is a Comprehensive Fatigue Panel?
Hormonal, metabolic, and blood health
Evaluates thyroid function (TSH, Free T4), morning cortisol, iron stores, CBC, and HbA1c to identify anemia, thyroid dysfunction, adrenal issues, and blood sugar problems that commonly drive fatigue.
Inflammation, autoimmune, and viral causes
Measures CRP, ESR, ANA, EBV antibodies, and screens for celiac disease and HIV — addressing immune and inflammatory contributors that are frequently overlooked in routine fatigue workups.
Nutritional status and organ function
Assesses Vitamin B12, folate, Vitamin D, and a comprehensive metabolic panel covering kidney, liver, and electrolyte function to catch deficiencies and organ-related causes of low energy.
Complete insights in days
1
Book your test
Instantly schedule at 2,000+ labs nationwide, at a time that works for you. Most visits take 15 minutes or less, with both walk-ins and appointments available.
2
Get clinician-reviewed results
Your results are delivered quickly—and reviewed by medical professionals. You’ll get clear explanations, robust health insights, and recommended next steps tailored to your health needs.
3
Take action with physician guidance
Choose to review your results and manage your plan with a General Medicine physician—or simply use the insights on your own.
4
Track progress over time
Repeat annually to see trends, improvements, and new emerging risks or book individual tests that focus on your set goals
All your care in one place. That’s the General Medicine difference.
We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.
What's included
Test type
Blood and Urine samples
Collection method
Venipuncture and Urine collection
Fasting
Required
Results processing time
1 to 5 days
Creatine Kinase (CK), Total
Measures an enzyme found mainly in muscles, the heart, and the brain. Elevated levels may point to muscle damage or inflammation that could contribute to fatigue.
Includes: CK Total
Tissue Transglutaminase (tTG) Antibody (IgA)
Detects antibodies associated with celiac disease. Undiagnosed celiac disease can cause chronic fatigue, nutrient malabsorption, and digestive symptoms.
Includes: tTG IgA
HIV-1/2 Antigen and Antibodies, Fourth Generation
Screens for HIV infection using a fourth-generation test that detects both antigens and antibodies. Undiagnosed HIV can present with persistent fatigue and other systemic symptoms.
Includes: HIV Ag/Ab with Reflexes
Vitamin B12 (Cobalamin)
Measures the level of vitamin B12 in your blood. Low B12 can lead to anemia, nerve problems, and significant fatigue.
Includes: Vitamin B12
TSH with Reflex to Free T4
Evaluates thyroid function by measuring thyroid-stimulating hormone. If TSH is abnormal, Free T4 is automatically added. Thyroid imbalances are a common cause of fatigue.
Includes: TSH; Free T4 if TSH is abnormal
Hemoglobin A1c with eAG
Reflects your average blood sugar over the past two to three months. Uncontrolled blood sugar—whether high or low—can cause ongoing tiredness.
Includes: HbA1c, Estimated Average Glucose
Iron, TIBC & Ferritin Panel
Measures iron levels, your body's iron-carrying capacity, and stored iron. Iron deficiency is one of the most common and treatable causes of fatigue.
Includes: Serum Iron, TIBC, Ferritin
Sed Rate (ESR)
A general marker of inflammation in the body. An elevated sed rate may suggest an underlying inflammatory or autoimmune condition contributing to fatigue.
Includes: Erythrocyte Sedimentation Rate
Gliadin (Deamidated) Antibody (IgG)
Detects antibodies related to gluten sensitivity and celiac disease. Used alongside tTG IgA to improve screening accuracy for celiac-related fatigue.
Includes: DGP IgG
Comprehensive Metabolic Panel (CMP)
Provides a broad snapshot of your metabolism, including kidney function, liver function, blood sugar, and electrolyte balance. Abnormalities in any of these areas can contribute to fatigue.
Includes: Glucose, BUN, Creatinine, Electrolytes, Liver Enzymes, Calcium, Protein, and more
CBC with Differential and Platelets
Evaluates the major components of your blood. It can reveal anemia, infection, or other blood-related conditions that commonly cause tiredness.
Includes: White Blood Cells, Red Blood Cells, Hemoglobin, Hematocrit, Platelets, Differential
Mono Screen (Heterophile Antibody)
Screens for infectious mononucleosis (mono), a viral illness known for causing extreme fatigue that can last weeks or months.
Includes: Heterophile Antibody
C-Reactive Protein (CRP)
Measures a protein produced by the liver in response to inflammation. Elevated CRP may indicate infection, autoimmune disease, or other inflammatory conditions linked to fatigue.
Includes: CRP
Vitamin D, 25-Hydroxy, Total
Measures your overall vitamin D level. Low vitamin D is widespread and has been associated with fatigue, muscle weakness, and mood changes.
Includes: Total Vitamin D
Folate, Serum
Measures the level of folate (vitamin B9) in your blood. Low folate can cause a type of anemia that leads to fatigue, weakness, and difficulty concentrating.
Includes: Serum Folate
ANA Screen (IFA) with Reflex to Titer and Pattern
Screens for antinuclear antibodies that may indicate an autoimmune condition such as lupus. Autoimmune disorders are a significant but sometimes overlooked cause of chronic fatigue.
Includes: ANA IFA; Titer and Pattern if positive
Cortisol, A.M.
Measures your cortisol level in the morning when it is normally at its peak. Abnormal cortisol levels can affect energy, stress response, and overall well-being.
Includes: Morning Cortisol
Ongoing support, always available.
You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.
Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.
What our customers have to say
Hear from people who felt heard, understood, and supported on General Medicine.
“I found the ease of setting the appointment and how quickly I was able to be seen to be amazing. The physician was very friendly and amazingly helpful.”
Natalie, Texas
“The chat visit was super convenient. The doctor was friendly and took the time needed to answer any questions I had. The prescription I needed was called in and ready the same afternoon.”
Dustin, Tennessee
“I loved my General Medicine experience. It gave me peace of mind to know someone cared and I felt they listened to what I was saying.”
Ann, Florida
“General Medicine is easily the most approachable, efficient, high-quality, and responsive care team I've had the pleasure of working with.”
John, Utah
“General Medicine helped me get the imaging and blood work I needed, referred me to the right specialists, and even helped me find a new family doctor.”
Bridget, Mississippi
Dive deeper: get the support you need to action against your goals
Explore additional services designed to go deeper, treat identified risks, or support specific health goals. General Medicine makes it easy to take the next step.
