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Comprehensive fatigue panel
Lab test

Comprehensive fatigue panel

Ordered for people with persistent tiredness that hasn't been explained by prior testing. Covers blood, urine, and multiple body systems in a single visit. Fasting required. Results are available within 1–5 days and reviewed by a General Medicine clinician.

Receive actionable insights and deep analysis—not just lab values– in as little as 48 hours

Clear guidance, and follow-up care available

Simple, online scheduling for labs and everything else

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

Complete insights in as little as 48 hours

1

Book your test

Instantly schedule at 2,000+ labs nationwide, at a time that works for you. Most visits take 15 minutes or less, with both walk-ins and appointments available.

2

Get results in 48 hours

Your results are delivered quickly—and reviewed by medical professionals. You’ll get clear explanations, robust health insights, and recommended next steps tailored to your health needs.

3

Take action with physician guidance

Choose to review your results and manage your plan with a General Medicine physician—or simply use the insights on your own.

4

Track progress over time

Repeat annually to see trends, improvements, and new emerging risks or book individual tests that focus on your set goals

What is a Comprehensive Fatigue Panel?

A Comprehensive Fatigue Panel is a broad blood and urine test designed to systematically identify the most common medical causes of persistent tiredness. It combines 76 biomarkers across multiple body systems — from thyroid and adrenal function to inflammation, autoimmune markers, and viral infections — to find what standard panels often miss.

Hormonal, metabolic, and blood health

Evaluates thyroid function (TSH, Free T4), morning cortisol, iron stores, CBC, and HbA1c to identify anemia, thyroid dysfunction, adrenal issues, and blood sugar problems that commonly drive fatigue.

Inflammation, autoimmune, and viral causes

Measures CRP, ESR, ANA, EBV antibodies, and screens for celiac disease and HIV — addressing immune and inflammatory contributors that are frequently overlooked in routine fatigue workups.

Nutritional status and organ function

Assesses Vitamin B12, folate, Vitamin D, and a comprehensive metabolic panel covering kidney, liver, and electrolyte function to catch deficiencies and organ-related causes of low energy.

What's included

Test type

Blood and Urine samples

Collection method

Venipuncture and Urine collection

Fasting

Required

Results processing time

1 to 5 days

CBC (Complete Blood Count)

Assesses overall blood health and detects conditions like anemia, infection, and immune disorders.

Includes: White Blood Cells (WBC), Red Blood Cells (RBC), Hemoglobin (Hgb), Platelet Count, Differential Counts

CMP (Comprehensive Metabolic Panel)

Evaluates kidney and liver function, blood sugar levels, and electrolyte balance.

Includes: Albumin, Calcium, Glucose, BUN/Creatinine Ratio, Liver Enzymes (ALT, AST), Electrolytes

Thyroid Panel

Evaluates metabolism and hormonal balance—key factors in fatigue.

Includes: TSH, Free T4 (FT4)

Hemoglobin A1c (HbA1c)

Reveals average blood sugar over 3 months to rule out diabetes or prediabetes.

Iron Panel

Evaluates iron levels and storage to assess for anemia or other iron-related conditions. Ferritin also serves as an inflammatory marker that can be elevated in infection, autoimmune conditions, or chronic disease.

Includes: Total Iron, Ferritin, Iron Binding Capacity, Transferrin Saturation

Inflammatory Markers

Detects inflammation, which may indicate infection, autoimmune disorders, or chronic disease.

Includes: C-Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESR)

Morning Cortisol

Measures cortisol levels to evaluate adrenal function and stress response.

Creatine Kinase (CK)

Assesses muscle health and detects muscle damage or disorders.

Vitamin Panel

Evaluates key vitamin levels that impact energy, nerve function, and overall wellness.

Includes: Vitamin B12, Folate, Vitamin D

HIV Screening

Detects HIV infection, which can impact immune function and energy levels.

EBV Panel (Epstein-Barr Virus)

Checks for Epstein-Barr virus, a common cause of chronic fatigue syndrome.

Autoimmune Screen (ANA)

Screens for autoimmune diseases that may contribute to chronic fatigue.

Celiac Disease Panel

Screens for celiac disease, which can cause fatigue due to nutrient malabsorption.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician
Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

What our customers have to say

Hear from people who felt heard, understood, and supported on General Medicine.

“I found the ease of setting the appointment and how quickly I was able to be seen to be amazing. The physician was very friendly and amazingly helpful.”

Natalie, Texas

“The chat visit was super convenient. The doctor was friendly and took the time needed to answer any questions I had. The prescription I needed was called in and ready the same afternoon.”

Dustin, Tennessee

“I loved my General Medicine experience. It gave me peace of mind to know someone cared and I felt they listened to what I was saying.”

Ann, Florida

“General Medicine is easily the most approachable, efficient, high-quality, and responsive care team I've had the pleasure of working with.”

John, Utah

“General Medicine helped me get the imaging and blood work I needed, referred me to the right specialists, and even helped me find a new family doctor.”

Bridget, Mississippi

Order your lab test today.

Frequently Asked Questions

What conditions can this panel detect?

The panel screens for the most common medical causes of persistent tiredness — including anemia, iron deficiency, thyroid dysfunction, prediabetes and diabetes, vitamin D deficiency, and liver or kidney issues. It measures 76 biomarkers across multiple body systems in a single blood draw.

Do I need to fast before this test?

Yes — fasting for 8–12 hours before your blood draw is recommended for the most accurate results, particularly for the blood sugar and metabolic markers included in the panel. Water is fine. Schedule your appointment for the morning if possible.

What if my results come back normal but I still feel exhausted?

Normal results are still valuable — they help rule out common correctable causes. A clinician can review your results alongside your symptoms and health history to determine whether further evaluation, specialist referral, or a different approach is warranted.

Is this test appropriate for both men and women?

Yes — the panel is designed for both. It includes hormones relevant to each, including testosterone, thyroid hormones, cortisol, and DHEA-S, alongside universal markers like iron stores, blood counts, and metabolic function.

How soon will I have results?

Results are typically available within 2–4 business days. A General Medicine clinician will review your results and can recommend next steps or book a same-day visit if further evaluation is needed.
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