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Colcrys (Colchicine)
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Colcrys (Colchicine)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Colcrys (Colchicine) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Colcrys (Colchicine)?

Colcrys is the branded formulation of colchicine, a prescription medication used to treat and prevent gout flares, and to treat familial Mediterranean fever (FMF). During a gout attack, uric acid crystals in joints trigger an intense inflammatory response driven by neutrophils. Colchicine works by interfering with the cellular mechanism that initiates and amplifies this inflammatory cascade—not by lowering uric acid, but by reducing how aggressively immune cells respond to the crystals. Taken at the first sign of a flare, it can significantly reduce severity; at low daily doses, it prevents recurring attacks.

Neutrophil microtubule disruption

Binds to tubulin and prevents microtubule polymerization in neutrophils—impairing their ability to migrate to the joint, engulf urate crystals, and release the inflammatory mediators that drive gout flare pain and swelling.

Rapid flare intervention

Most effective when taken at the very first sign of a gout attack. Early dosing can dramatically reduce the severity and duration of the flare before the full inflammatory cascade becomes established.

FMF management

For familial Mediterranean fever, daily Colcrys reduces the frequency and severity of the recurrent fever and serositis episodes caused by inherited abnormalities in the inflammasome pathway—providing meaningful disease control with long-term use.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

What is Colcrys specifically approved for?

Colcrys is the FDA-approved branded colchicine used to treat acute gout flares, prevent recurring gout attacks at lower daily doses, and treat familial Mediterranean fever — a rare inherited inflammatory condition.

When should I take Colcrys during a gout attack?

Take it at the very first sign of a flare — ideally within the first 12–24 hours of onset. Starting early, when inflammation is just beginning, dramatically improves how well it works to shorten and reduce the attack.

Does Colcrys lower my uric acid levels?

No. Colcrys reduces the inflammatory response to urate crystals but does not lower uric acid production or excretion. Separate urate-lowering medications like allopurinol or febuxostat are needed for long-term uric acid management.

What side effects might I experience?

Diarrhea, nausea, vomiting, and abdominal cramping are most common — particularly at the higher doses used for acute flares. These are dose-dependent; the lower preventive dose is typically much better tolerated.

Does Colcrys interact with other medications?

Yes — significantly. Colcrys interacts with statins, cyclosporine, and several other common medications, increasing the risk of muscle toxicity or other serious effects. Always review your full medication list with your clinician before use.
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