Colchicine

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What is Colchicine?

Colchicine is a prescription medication used to treat and prevent gout flares, and to treat pericarditis (inflammation around the heart). During a gout attack, uric acid crystals deposit in joints, triggering an intense inflammatory response. Colchicine works by interfering with the cellular mechanism that initiates and amplifies this inflammatory cascade—not by lowering uric acid levels, but by reducing how aggressively the immune system responds to the crystals. It's taken at the first sign of a flare for acute treatment, or at low daily doses to prevent recurring attacks.

Neutrophil disruption

Interferes with microtubule formation in neutrophils—the white blood cells that rush to joints in response to uric acid crystals—preventing them from activating and amplifying the inflammatory response.

Rapid flare intervention

Most effective when taken at the very first sign of a gout attack. Early dosing can dramatically reduce the severity and duration of the flare before full inflammation sets in.

Prevention at low doses

Taken daily at a low dose between flares, Colchicine significantly reduces the frequency of gout attacks—without directly altering uric acid levels or requiring the same doses used for acute treatment.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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