General
Bupropion (Wellbutrin)
Virtual visit

Bupropion (Wellbutrin)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Bupropion (Wellbutrin) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Bupropion (Wellbutrin)?

Bupropion is an antidepressant that works differently from SSRIs—instead of targeting serotonin, it increases levels of dopamine and norepinephrine, two neurotransmitters that influence mood, motivation, and focus. It's prescribed for depression, seasonal affective disorder, and under the brand name Zyban, for smoking cessation. Many patients find it energizing rather than sedating, and it's less likely than other antidepressants to cause weight gain or sexual side effects. It's taken once or twice daily depending on the formulation.

Dopamine and norepinephrine reuptake inhibition

Increases availability of dopamine and norepinephrine in the brain—neurotransmitters associated with motivation, reward, and energy—rather than primarily targeting serotonin like most antidepressants.

Activating profile

Tends to be stimulating rather than sedating, which can be helpful for patients who experience fatigue, low motivation, or cognitive sluggishness as part of their depression.

Favorable side effect profile

Less likely to cause the sexual dysfunction, weight gain, or emotional blunting that are common complaints with SSRI and SNRI antidepressants.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How is Wellbutrin different from SSRIs?

Bupropion targets dopamine and norepinephrine rather than serotonin, producing a different side effect profile — less sexual dysfunction, less sedation, and less weight gain than most SSRIs, with a mildly activating quality.

How long before I notice it working?

Energy and motivation often improve before mood does. Most people begin noticing mood changes within 2–4 weeks, with full antidepressant effect typically reached around 4–6 weeks of consistent use.

Can bupropion help me quit smoking?

Yes. Under the brand name Zyban, bupropion is FDA-approved for smoking cessation. The same dopamine mechanism that helps with depression also reduces nicotine cravings and withdrawal symptoms.

What side effects might I experience?

Dry mouth, insomnia, headache, and nausea are most common, especially in the first couple of weeks. Bupropion lowers the seizure threshold slightly — particularly at higher doses — which is an important consideration.

Does bupropion cause weight gain?

Bupropion is one of the few antidepressants that is weight-neutral or may support modest weight loss in some people — a meaningful difference from SSRIs and SNRIs that commonly cause weight gain.
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