General
Benzaclin (clindamycin/benzoyl peroxide)
Virtual visit

Benzaclin (clindamycin/benzoyl peroxide)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Benzaclin (clindamycin/benzoyl peroxide) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Benzaclin (clindamycin/benzoyl peroxide)?

Benzaclin is a prescription topical gel combining clindamycin, an antibiotic, with benzoyl peroxide, an antimicrobial and keratolytic agent, for the treatment of acne. The combination addresses acne through complementary mechanisms—clindamycin reduces the bacteria that drive inflammatory breakouts, while benzoyl peroxide kills bacteria through oxidative activity and helps prevent clindamycin resistance from developing. Applied once or twice daily, it's effective for both inflammatory papules and pustules. The combination is clinically superior to either ingredient alone and is one of the most commonly prescribed topical acne regimens.

Antibiotic bacterial suppression

Clindamycin inhibits bacterial protein synthesis in Cutibacterium acnes, reducing the bacterial population within follicles that triggers the inflammatory response behind papules and pustules.

Benzoyl peroxide resistance prevention

Benzoyl peroxide generates reactive oxygen species that kill C. acnes through a non-antibiotic mechanism—its inclusion alongside clindamycin significantly reduces the risk of antibiotic resistance developing with long-term use.

Combination synergy

Clindamycin and benzoyl peroxide attack acne-causing bacteria through two independent mechanisms simultaneously, producing greater antibacterial and anti-inflammatory efficacy than either agent alone—making the combination a preferred first-line topical acne treatment.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

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Frequently Asked Questions

How is BenzaClin different from using clindamycin alone?

Adding benzoyl peroxide to clindamycin provides two important advantages: it kills bacteria through a second independent mechanism for greater effectiveness, and it significantly reduces the risk of antibiotic resistance developing with long-term use.

How long before BenzaClin improves my acne?

Most people notice meaningful reduction in inflammatory lesions — papules and pustules — within 8–12 weeks of once or twice-daily use. Full results continue developing over 3–4 months of consistent treatment.

Can BenzaClin bleach my clothes or pillow?

Yes. Benzoyl peroxide is a bleaching agent — it can stain or discolor fabric including clothing, bedding, and towels. Allow it to fully absorb before contact with fabric, and consider using white pillowcases.

What side effects might I experience?

Dryness, peeling, redness, and skin irritation are most common — particularly in the first few weeks as skin adjusts. Using a non-comedogenic moisturizer helps manage dryness. Starting with once-daily application reduces early irritation.

Should I apply BenzaClin to the entire face or just pimples?

Apply a thin layer to the entire affected area — not just individual pimples. Treating the whole area helps prevent new breakouts from forming and is more effective than spot treatment alone.
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