Benlysta

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What is Benlysta?

Benlysta is a biologic medication approved for the treatment of active systemic lupus erythematosus (SLE) and lupus nephritis in adults and children aged 5 and older. It's the first new lupus treatment approved in more than 50 years. Benlysta works by targeting BLyS (B lymphocyte stimulator), a protein that promotes the survival of autoreactive B cells—the immune cells that produce the self-attacking antibodies responsible for lupus organ damage. By blocking BLyS, Benlysta reduces the survival of these harmful B cells, lowering autoantibody levels and reducing flares and organ damage over time. It's given as a monthly IV infusion or weekly subcutaneous injection.

BLyS inhibition

Binds to and blocks B lymphocyte stimulator (BLyS), a survival factor for autoreactive B cells—reducing the population of B cells that produce the anti-dsDNA and other autoantibodies that drive lupus inflammation and organ damage.

Autoantibody reduction

By limiting the survival of BLyS-dependent autoreactive B cells, Benlysta lowers circulating autoantibody levels over time, reducing the immune complex deposition that causes lupus nephritis, joint inflammation, and other organ involvement.

Flare rate reduction

Clinical trials demonstrated meaningful reductions in lupus flare frequency and severity with Benlysta—allowing some patients to reduce corticosteroid use and better protect vital organs from the cumulative damage of repeated inflammatory episodes.

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