Baclofen

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What is Baclofen?

Baclofen is a muscle relaxant and antispastic medication primarily prescribed for spasticity—the chronic muscle stiffness, spasms, and involuntary contractions associated with conditions like multiple sclerosis, spinal cord injury, and cerebral palsy. Unlike medications that act on the muscle itself, Baclofen works in the spinal cord to reduce the excessive nerve signals that cause muscles to stay in a contracted state. It's taken orally several times daily, with doses gradually increased to achieve the best balance between muscle relaxation and manageable side effects like drowsiness.

GABA-B receptor activation

Activates inhibitory GABA-B receptors in the spinal cord, reducing the release of excitatory neurotransmitters that drive abnormal muscle tone, spasms, and involuntary contractions.

Spasticity relief

By calming overactive spinal reflexes, Baclofen reduces the painful, disabling muscle stiffness and spasms that interfere with movement, comfort, and daily function in conditions like MS and spinal cord injury.

Central mechanism

Works at the level of the spinal cord rather than directly on muscle tissue, allowing it to address neurologically driven spasticity more precisely than peripherally acting muscle relaxants.

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Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

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