General
Baclofen (Lioresal)
Virtual visit

Baclofen (Lioresal)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Baclofen (Lioresal) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Baclofen (Lioresal)?

Baclofen is a muscle relaxant and antispastic medication primarily prescribed for spasticity—the chronic muscle stiffness, spasms, and involuntary contractions associated with conditions like multiple sclerosis, spinal cord injury, and cerebral palsy. Unlike medications that act on the muscle itself, Baclofen works in the spinal cord to reduce the excessive nerve signals that cause muscles to stay in a contracted state. It's taken orally several times daily, with doses gradually increased to achieve the best balance between muscle relaxation and manageable side effects like drowsiness.

GABA-B receptor activation

Activates inhibitory GABA-B receptors in the spinal cord, reducing the release of excitatory neurotransmitters that drive abnormal muscle tone, spasms, and involuntary contractions.

Spasticity relief

By calming overactive spinal reflexes, Baclofen reduces the painful, disabling muscle stiffness and spasms that interfere with movement, comfort, and daily function in conditions like MS and spinal cord injury.

Central mechanism

Works at the level of the spinal cord rather than directly on muscle tissue, allowing it to address neurologically driven spasticity more precisely than peripherally acting muscle relaxants.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
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What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

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Get the care you need, without the wait.

Frequently Asked Questions

How long before baclofen reduces my muscle spasms?

Some people notice spasm reduction within the first few days, but the dose is usually increased gradually over several weeks. Full benefit may take 4–8 weeks to establish at an effective dose.

Can I stop taking it suddenly?

No. Stopping baclofen abruptly — especially at higher doses — can trigger serious withdrawal symptoms including seizures, hallucinations, and dangerous rebound spasticity. Always taper gradually under your clinician's supervision.

Will baclofen make me drowsy?

Drowsiness is one of the most common side effects, particularly at higher doses and when starting treatment. It often improves over time as the body adjusts. Avoid alcohol and sedating medications while on baclofen.

What side effects might I experience?

Drowsiness, dizziness, weakness, fatigue, nausea, and headache are most common. Confusion can occur in older adults. Most side effects are dose-dependent and improve with dose adjustment.

Is baclofen addictive?

Baclofen is not classified as a controlled substance and is not considered addictive in the traditional sense. However, physical dependence develops with regular use — which is why stopping gradually is essential.
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