General
Azelex (azelaic acid)
Virtual visit

Azelex (azelaic acid)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Azelex (azelaic acid) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Azelex (azelaic acid)?

Azelex is a prescription topical cream containing 20% azelaic acid, used to treat mild to moderate acne. It works through multiple complementary mechanisms—killing acne-causing bacteria, normalizing the follicular keratinization that leads to clogged pores, and reducing the post-inflammatory hyperpigmentation that acne can leave behind. Unlike retinoids or benzoyl peroxide, azelaic acid is generally well-tolerated by sensitive skin and is safe during pregnancy, making it a useful option for patients who can't use other topical acne medications. It's applied twice daily to the entire affected area.

Antibacterial and antikeratinizing activity

Kills Cutibacterium acnes within follicles while simultaneously normalizing the abnormal keratinization that causes pores to clog—addressing two of the primary drivers of acne through a single ingredient.

Post-inflammatory hyperpigmentation reduction

Inhibits tyrosinase, the enzyme involved in melanin production, reducing the dark spots and uneven skin tone that frequently follow acne breakouts—providing both acne treatment and pigmentation correction.

Pregnancy-safe tolerability

One of the few topical acne treatments considered safe during pregnancy, and generally well-tolerated by sensitive or rosacea-prone skin—making it a valuable option when retinoids, benzoyl peroxide, or antibiotics aren't appropriate.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

What does Azelex treat?

Azelex is a prescription 20% azelaic acid cream used to treat mild to moderate acne. It reduces acne-causing bacteria, normalizes skin cell shedding to prevent pore clogging, and fades the dark spots that breakouts leave behind.

How long before Azelex clears my acne?

Most people see meaningful improvement after 4–8 weeks of consistent twice-daily use. Full results typically develop over 3–6 months. Azelex works gradually — it's not a fast-acting acne treatment.

Is Azelex safe for sensitive skin?

Yes — azelaic acid is one of the gentler topical acne treatments available, making it well suited for people with sensitive, rosacea-prone, or easily irritated skin who haven't tolerated retinoids or benzoyl peroxide.

What side effects might I experience?

Temporary burning, stinging, tingling, and itching at the application site are most common — especially in the first few weeks. Dryness and mild peeling can also occur. These typically improve as skin adjusts.

Is Azelex safe to use during pregnancy?

Azelaic acid is considered one of the safer topical acne treatments during pregnancy and is often recommended as an alternative to retinoids and certain antibiotics that are contraindicated in pregnancy. Confirm with your clinician.
Logo

© 2026 Path Healthcare Systems Corp.