Azelex

Without insurance

With insurance

Compare prices at 50K+ pharmacies nationwide

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Azelex?

Azelex is a prescription topical cream containing 20% Azelex, used to treat mild to moderate acne. It works through multiple complementary mechanisms—killing acne-causing bacteria, normalizing the follicular keratinization that leads to clogged pores, and reducing the post-inflammatory hyperpigmentation that acne can leave behind. Unlike retinoids or benzoyl peroxide, Azelex is generally well-tolerated by sensitive skin and is safe during pregnancy, making it a useful option for patients who can't use other topical acne medications. It's applied twice daily to the entire affected area.

Antibacterial and antikeratinizing activity

Kills Cutibacterium acnes within follicles while simultaneously normalizing the abnormal keratinization that causes pores to clog—addressing two of the primary drivers of acne through a single ingredient.

Post-inflammatory hyperpigmentation reduction

Inhibits tyrosinase, the enzyme involved in melanin production, reducing the dark spots and uneven skin tone that frequently follow acne breakouts—providing both acne treatment and pigmentation correction.

Pregnancy-safe tolerability

One of the few topical acne treatments considered safe during pregnancy, and generally well-tolerated by sensitive or rosacea-prone skin—making it a valuable option when retinoids, benzoyl peroxide, or antibiotics aren't appropriate.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

Thousands of customers trust us

“I feel like I'm finally on the right path to improving my health with the right support now! It's so refreshing and reassuring.”

—Emerald, Texas

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

—Kaylee, Louisiana

“I couldn't be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

—Nika, Tennessee

Dive deeper: get the support you need

Your health rarely comes down to just one thing. If your clinician identifies related needs during your visit, we can help address them through additional services.

Medications

We will write your prescription and send it to your pharmacy

Lab tests

See cost up front and book your lab test instantly

Dermatology

Get a specialist consult or talk to a clinician about your condition

Travel needs

Going on a big trip? Get the vaccines and medications you need

Everyday care

No waitlist, rushed visits, or hidden fees—get care fast.

Frequently asked questions

What is General Medicine?

What can General Medicine help with?

General Medicine provides convenient care for all of your of health needs, including common and chronic conditions, specialist consultations, and preventative care. We make it easy to get the care you need—whether it's getting the right prescriptions, labs or imaging, or connecting you with the right specialists or in-person providers—ensuring your healthcare experience is seamless and stress-free.

How much does General Medicine cost?

Who is the care team at General Medicine?

How do you protect my health information?