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Apresoline (hydralazine)
Virtual visit

Apresoline (hydralazine)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Apresoline (hydralazine) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Apresoline (hydralazine)?

Apresoline is a direct-acting vasodilator used to treat high blood pressure, particularly in cases where other medications haven't achieved adequate control or aren't appropriate—such as during pregnancy-related hypertension. It works by directly relaxing the smooth muscle in arterial walls, causing blood vessels to widen and blood pressure to drop. Because it acts so directly on blood vessels, it often causes reflex heart rate increases, which is why it's frequently combined with a beta-blocker. It's taken orally two to four times daily, and an IV form is used in hospital settings for hypertensive emergencies.

Direct arterial vasodilation

Relaxes smooth muscle in arteriolar walls through mechanisms that involve interference with calcium release and utilization, causing blood vessels to dilate and peripheral vascular resistance—and therefore blood pressure—to fall.

Pregnancy hypertension use

One of the few antihypertensives with a long safety record in pregnancy, making it a go-to option for managing hypertension in pregnant patients when beta-blockers or ACE inhibitors are not appropriate.

Reflex tachycardia consideration

The rapid blood pressure reduction triggers a compensatory reflex increase in heart rate—which is why Hydralazine is commonly paired with a beta-blocker to counteract this effect and improve tolerability.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

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What our customers have to say

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Frequently Asked Questions

What is hydralazine most commonly used for?

Hydralazine is used for high blood pressure that hasn't been adequately controlled with other medications. It's also one of the preferred antihypertensives during pregnancy, where many common blood pressure drugs are contraindicated.

Why is hydralazine often prescribed with a beta-blocker?

Hydralazine causes a reflex increase in heart rate as blood pressure drops. A beta-blocker is commonly co-prescribed to counteract this, improving both tolerability and overall blood pressure control.

How quickly does hydralazine lower blood pressure?

Oral hydralazine typically begins lowering blood pressure within 20–30 minutes and reaches peak effect within 1–2 hours. IV hydralazine used in hospital settings for hypertensive emergencies works even faster.

What side effects might I experience?

Headache, rapid heartbeat, flushing, dizziness, and nausea are most common. Long-term use at higher doses can rarely cause a lupus-like syndrome — joint pain, rash, and fever — that resolves when the medication is stopped.

Is hydralazine safe during pregnancy?

Yes — hydralazine has one of the longest safety records of any antihypertensive used in pregnancy. It's frequently used for acute management of severe hypertension in pregnant patients in hospital settings.
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