Amitriptyline-perphenazine
Rather than managing two separate conditions with two separate prescriptions, amitriptyline-perphenazine is written as one combination. After you book, your clinician reviews your history so your visit is about finding the right fit for you, whether that's amitriptyline-perphenazine or another option.
Addresses depression and anxiety or agitation in a single medication
A practical option when both antidepressant and antipsychotic coverage are needed
Available as a low-cost generic
Visit options
Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.
Video Visit
$25
Est. or $100 w/o insurance
Chat Visit
$30
w/o insurance
Most insurance accepted
Board-certified clinicians
No hidden fees
Available nationwide
What is Amitriptyline - Perphenazine?
Amitriptyline-perphenazine is a combination medication pairing a tricyclic antidepressant (amitriptyline) with a typical antipsychotic (perphenazine), used to treat moderate to severe anxiety and depression—particularly when both conditions are present together, or when depression is accompanied by agitation or psychotic features. Amitriptyline improves mood through serotonin and norepinephrine reuptake inhibition, while perphenazine's dopamine blockade addresses agitation, anxiety, and in some cases mild psychotic symptoms that can accompany severe depression. It's taken once or multiple times daily depending on the formulation.
Dual antidepressant and antipsychotic activity
Amitriptyline blocks reuptake of serotonin and norepinephrine to address the depressive component, while perphenazine blocks dopamine D2 receptors to reduce agitation, anxiety, and psychotic features that sometimes accompany severe depression.
Comorbid anxiety-depression treatment
The combination is particularly suited to patients with moderate-to-severe depression accompanied by significant anxiety, agitation, or mixed features—addressing both the mood and the behavioral or psychotic components simultaneously.
Sedation and anticholinergic profile
The combination of amitriptyline's antihistamine and anticholinergic activity with perphenazine's sedating properties produces significant sedation—which can be therapeutically useful for patients with severe anxiety and insomnia but requires awareness of cognitive and other anticholinergic side effects.
Ongoing support, always available.
You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.
Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.
All your care in one place. That’s the General Medicine difference.
We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.
What our customers have to say
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