General
Aczone (Dapsone)
Virtual visit

Aczone (Dapsone)

With our quick and easy online prescription process, you can manage your health effortlessly — whether you need a first-time prescription for Aczone (Dapsone) or a refill of an existing one.

Licensed providers in all 50 states

Expert-guided, evidence-based treatments

Skip the trip to the doctor's office

Visit options

Costs shown are for the visit only. You'll pay for medication at your preferred pharmacy.

Video Visit

$25

Est. or $100 w/o insurance

Chat Visit

$30

w/o insurance

Most insurance accepted

Board-certified

No hidden fees

Available nationwide

What is Aczone (Dapsone)?

Aczone is a prescription topical gel containing dapsone, an antimicrobial agent, used to treat acne vulgaris in patients 12 years and older. Unlike retinoids or benzoyl peroxide, dapsone works through anti-inflammatory and antimicrobial mechanisms—reducing the inflammatory acne lesions (papules and pustules) without the dryness and irritation associated with other topical acne treatments. It's applied once or twice daily to the entire face and is particularly well-tolerated, making it a useful option for patients with sensitive skin or those who haven't tolerated other topical acne medications.

Antimicrobial activity

Inhibits bacterial dihydropteroate synthase, disrupting folate synthesis in Cutibacterium acnes—reducing the bacterial population within follicles that triggers the inflammatory response behind acne breakouts.

Anti-inflammatory mechanism

Beyond its antimicrobial action, Dapsone suppresses neutrophil activity and oxidative tissue damage at the site of acne lesions, directly reducing the redness, swelling, and pain of inflammatory papules and pustules.

Tolerability advantage

Produces significantly less skin dryness, peeling, and irritation than retinoids or benzoyl peroxide-based treatments—making it a particularly valuable option for patients with sensitive skin or those who have experienced intolerance with other topical acne therapies.

Virtual visit with clinician

Ongoing support, always available.

You’ll be supported by experienced clinicians who care for a wide range of health needs, from everyday concerns to more complex conditions.

Our clinicians track your progress over time and adjust your care as needed. If medication is prescribed, we’ll manage dosing and monitor for side effects. If lab testing is recommended, we review results and refine your plan accordingly. You’re never left to navigate care on your own.

All your care in one place. That’s the General Medicine difference.

We help you understand your options, connect you to the right clinicians, manage prescriptions, coordinate any needed evaluations, and keep an eye on your overall health along the way. It’s comprehensive care that looks at the full picture — your goals, your history, your lifestyle — and makes it simple to move forward with confidence.

Your care plan
Clinician

What our customers have to say

“I feel like I’m finally on the right path to improving my health with the right support now! It’s so refreshing and reassuring.”

Emerald

“My experience with General Medicine was amazing. The understanding and care that was taken to figure out what is exactly going on with me. I feel like a weight has been lifted off of me.”

Kaylee

“I couldn’t be happier with my experience with General Medicine! They are fast, responsive, kind and knowledgeable. It is much easier, more affordable and faster.”

Nika

Get the care you need, without the wait.

Frequently Asked Questions

How long does Aczone take to clear acne?

Clinical trials showed meaningful improvement in inflammatory acne after 12 weeks of once or twice-daily use. Full results continue developing over 3–6 months of consistent treatment — patience is important.

Why is Aczone recommended for sensitive skin?

Aczone causes significantly less dryness, peeling, and irritation than retinoids or benzoyl peroxide — making it well suited for people with sensitive or rosacea-prone skin who haven't tolerated other topical acne treatments.

Can I use Aczone alongside other acne treatments?

Aczone can be combined with other topical treatments in many cases, but avoid using it simultaneously with products containing benzoyl peroxide — this combination can cause temporary orange or brown skin staining.

What side effects might I experience?

Oiliness, peeling, dryness, redness, and burning at the application site are the most commonly reported effects — and they're milder than most other topical acne medications. Systemic side effects are rare with topical use.

Is Aczone safe to use during pregnancy?

Limited safety data exists for topical dapsone during pregnancy. Consult your clinician before using Aczone if you are pregnant or planning to become pregnant — alternative acne treatments with better pregnancy safety data may be preferred.
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