Aczone

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What is Aczone?

Aczone is a prescription topical gel containing dapsone, an antimicrobial agent, used to treat acne vulgaris in patients 12 years and older. Unlike retinoids or benzoyl peroxide, Aczone works through anti-inflammatory and antimicrobial mechanisms—reducing the inflammatory acne lesions (papules and pustules) without the dryness and irritation associated with other topical acne treatments. It's applied once or twice daily to the entire face and is particularly well-tolerated, making it a useful option for patients with sensitive skin or those who haven't tolerated other topical acne medications.

Antimicrobial activity

Inhibits bacterial dihydropteroate synthase, disrupting folate synthesis in Cutibacterium acnes—reducing the bacterial population within follicles that triggers the inflammatory response behind acne breakouts.

Anti-inflammatory mechanism

Beyond its antimicrobial action, Aczone suppresses neutrophil activity and oxidative tissue damage at the site of acne lesions, directly reducing the redness, swelling, and pain of inflammatory papules and pustules.

Tolerability advantage

Produces significantly less skin dryness, peeling, and irritation than retinoids or benzoyl peroxide-based treatments—making it a particularly valuable option for patients with sensitive skin or those who have experienced intolerance with other topical acne therapies.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

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