Aripiprazole

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What is Aripiprazole?

Aripiprazole is an atypical antipsychotic used to treat schizophrenia, bipolar disorder, major depressive disorder (as an add-on treatment), irritability associated with autism spectrum disorder, and Tourette's disorder. Unlike older antipsychotics that broadly block dopamine receptors, Aripiprazole acts as a partial agonist—meaning it both activates and moderates dopamine activity depending on whether levels are too high or too low. This nuanced mechanism is why it's often better tolerated than other antipsychotics, with less risk of weight gain, sedation, and metabolic effects.

Partial dopamine agonism

Acts as a partial agonist at D2 receptors—stabilizing dopamine activity by activating receptors when dopamine is too low and competing with excess dopamine when it's too high, producing more balanced neurotransmitter regulation.

Serotonin modulation

Also acts as a partial agonist at 5-HT1A receptors and an antagonist at 5-HT2A receptors, contributing to its effectiveness for depression and anxiety symptoms alongside its antipsychotic action.

Favorable tolerability profile

Less likely than many antipsychotics to cause significant weight gain, sedation, or metabolic changes—making it a preferred option for long-term maintenance treatment in conditions like bipolar disorder and schizophrenia.

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