General MedicineGeneral Medicine
Vyleesi

Vyleesi

Without insurance

With insurance

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Vyleesi?

Vyleesi is a prescription injectable medication approved for premenopausal women with hypoactive sexual desire disorder (HSDD)—a condition marked by persistently low sexual desire that causes personal distress. Unlike Addyi, which is taken daily, Vyleesi is used on-demand—injected into the abdomen or thigh 45 minutes before anticipated sexual activity and used no more than once per 24 hours. It works by activating melanocortin receptors in the brain that are involved in sexual motivation and arousal. The most common side effect is temporary nausea after injection.

Melanocortin receptor activation

Activates MC3R and MC4R receptors in the central nervous system, stimulating neural pathways associated with sexual motivation and arousal through a mechanism distinct from hormonal or vascular treatments.

On-demand dosing

Taken only when desired, 45 minutes before sexual activity—offering a situational approach to HSDD for women who prefer not to take a daily medication or who don't respond to Addyi.

Non-hormonal brain-based mechanism

Works through the central nervous system's melanocortin system rather than sex hormones, making it an option for women who want or need to avoid estrogen- or testosterone-based therapies.

Virtual visit with clinician

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

5 out of 5 stars on Trustpilot

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

5 out of 5 stars on Trustpilot

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

5 out of 5 stars on Trustpilot

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

5 out of 5 stars on Trustpilot

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

5 out of 5 stars on Trustpilot

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

5 out of 5 stars on Trustpilot

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

5 out of 5 stars on Trustpilot

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