Viibryd

Brand for vilazodone

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Available nationwide

What is Viibryd?

Viibryd is a prescription antidepressant approved for major depressive disorder that combines two mechanisms in a single molecule: serotonin reuptake inhibition (like an SSRI) and partial agonism at the 5-HT1A serotonin receptor. This dual action is designed to provide more complete serotonergic modulation than SSRIs alone—potentially improving antidepressant efficacy and reducing anxiety symptoms. It's taken once daily with food and requires gradual dose titration over two weeks to reach the therapeutic dose. Some patients find it has a more favorable sexual side effect profile compared to standard SSRIs.

Serotonin reuptake inhibition plus 5-HT1A partial agonism

Combines SSRI-level serotonin transporter blockade with partial activation of presynaptic 5-HT1A autoreceptors—the dual action reduces the autoreceptor-mediated feedback that can blunt SSRI response and enhances overall serotonergic tone.

Anxiety symptom targeting

The 5-HT1A partial agonism provides an anxiolytic effect similar to buspirone—potentially offering broader relief for the anxiety symptoms that frequently accompany major depression.

Titrated dosing with food

Started at a low dose and increased over 2 weeks to minimize GI side effects, and taken with food to improve absorption and tolerability—gradual titration is essential for establishing the therapeutic dose comfortably.

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Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

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