Trulance

Without insurance

With insurance

Compare prices at 50K+ pharmacies nationwide

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Trulance?

Trulance is a prescription medication used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults. It works locally in the upper gastrointestinal tract, mimicking a naturally occurring gut hormone called uroguanylin that activates fluid and electrolyte secretion into the intestine. This increases the fluid content of the bowel and accelerates transit, softening stool and making bowel movements more frequent and easier to pass. Like Linzess, it works within the gut without meaningful systemic absorption, and is taken once daily on an empty stomach.

Guanylate cyclase-C agonism

Binds to and activates GC-C receptors in intestinal epithelial cells, stimulating cAMP and cGMP production that drives chloride and bicarbonate secretion into the gut lumen—increasing intestinal fluid and accelerating colonic transit.

pH-dependent upper GI activation

Trulance is uniquely designed to activate primarily in the slightly acidic environment of the upper small intestine, closely mimicking the site and conditions under which natural uroguanylin acts—a physiologically targeted approach.

Local gut-only action

Minimal systemic absorption means Trulance's entire therapeutic effect is confined to the GI tract, reducing the potential for systemic side effects while concentrating its fluid-secreting and motility-enhancing activity exactly where it's needed.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

Dive deeper: get the support you need

Your health rarely comes down to just one thing. If your clinician identifies related needs during your visit, we can help address them through additional services.

Medications

We will write your prescription and send it to your pharmacy

Lab tests

See cost up front and book your lab test instantly

Dermatology

Get a specialist consult or talk to a clinician about your condition

Travel needs

Going on a big trip? Get the vaccines and medications you need

Everyday care

No waitlist, rushed visits, or hidden fees—get care fast.

Frequently asked questions

What is General Medicine?

What can General Medicine help with?

General Medicine provides convenient care for all of your of health needs, including common and chronic conditions, specialist consultations, and preventative care. We make it easy to get the care you need—whether it's getting the right prescriptions, labs or imaging, or connecting you with the right specialists or in-person providers—ensuring your healthcare experience is seamless and stress-free.

How much does General Medicine cost?

Who is the care team at General Medicine?

How do you protect my health information?