Tri-Luma

Brand for hydroquinone

Without insurance

With insurance

Compare prices at 50K+ pharmacies nationwide

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Tri-Luma?

Tri-Luma is a prescription topical cream containing three active ingredients—fluocinolone (a corticosteroid), hydroquinone (a skin lightener), and tretinoin (a retinoid)—specifically formulated to treat melasma, a condition that causes brown or gray-brown patches on the face. Each ingredient addresses a different aspect of the condition: hydroquinone reduces melanin production, tretinoin increases skin cell turnover to fade existing pigment, and fluocinolone reduces the inflammation that can worsen discoloration. It's applied once nightly and used alongside strict sun protection.

Triple-action pigment correction

Hydroquinone inhibits the enzyme tyrosinase to reduce new melanin production, tretinoin accelerates the shedding of pigmented skin cells, and fluocinolone calms inflammation that drives melanin overproduction—all three mechanisms working together.

Retinoid-enhanced cell turnover

Tretinoin speeds up epidermal renewal, bringing fresh, less-pigmented cells to the surface faster while also enhancing penetration of the other active ingredients into the skin.

Anti-inflammatory stabilization

The corticosteroid component reduces post-inflammatory hyperpigmentation—a common driver of melasma worsening—while also helping the skin tolerate the potentially irritating effects of hydroquinone and tretinoin together.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

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