Skyrizi

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Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Skyrizi?

Skyrizi is a biologic injectable medication used to treat moderate-to-severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It works by specifically targeting interleukin-23 (IL-23), a protein that plays a central role in driving the chronic inflammation responsible for these conditions. By blocking IL-23, Skyrizi interrupts the inflammatory cascade upstream—before it triggers the immune cells that cause skin plaques, joint inflammation, and intestinal damage. For psoriasis, it's given as two injections at week 0 and 4, then every 12 weeks.

Selective IL-23 inhibition

Binds to the p19 subunit of IL-23, blocking this cytokine's ability to activate Th17 immune cells — the primary drivers of the chronic skin, joint, and intestinal inflammation in its approved indications.

Upstream pathway blockade

By targeting IL-23 before it triggers downstream inflammatory cascades, Skyrizi interrupts the inflammation earlier and more completely than treatments that block end-stage cytokines like IL-17.

High and durable response rates

Clinical trials show that a large proportion of people with plaque psoriasis achieve clear or almost clear skin — with response rates that hold up or improve over time with the every-12-week maintenance dosing schedule.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

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