Nocdurna

Brand for Desmopressin

Without insurance

With insurance

Compare prices at 50K+ pharmacies nationwide

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Nocdurna?

Nocdurna is a low-dose sublingual desmopressin tablet specifically formulated to treat nocturia — waking up one or more times during the night to urinate — due to nocturnal polyuria (producing too much urine at night). It works by mimicking ADH (antidiuretic hormone), the natural hormone that signals the kidneys to concentrate urine and reduce urine output during sleep. Nocdurna comes in sex-specific doses — a lower dose for women and a higher dose for men — reflecting differences in how the drug is metabolized. It's placed under the tongue at least one hour before bed.

ADH receptor activation

Binds to V2 receptors in the kidney collecting ducts, mimicking the natural antidiuretic hormone signal that causes the kidneys to reabsorb water and concentrate urine—reducing nighttime urine production.

Nocturnal polyuria targeting

Specifically addresses the nighttime overproduction of urine that disrupts sleep, rather than treating overall bladder capacity or urgency—making it distinct from other overactive bladder medications.

Sex-differentiated dosing

Available in separate formulations for men and women based on pharmacokinetic differences—women are prescribed a lower dose due to slower clearance, which reduces the risk of hyponatremia (low sodium) that can occur with excessive Nocdurna activity.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

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