Lotrel

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Compare prices at 50K+ pharmacies nationwide

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Lotrel?

Lotrel is a combination blood pressure medication containing amlodipine, a calcium channel blocker, and benazepril, an ACE inhibitor. Together, these two medications lower blood pressure through two distinct and complementary mechanisms, providing greater reduction than either drug alone. Amlodipine relaxes the walls of blood vessels by blocking calcium entry into smooth muscle cells, while benazepril reduces the production of angiotensin II — a potent vasoconstrictor and driver of fluid retention. Combining them in one tablet simplifies the regimen and improves adherence for people who need dual therapy. It's taken once daily.

Dual complementary blood pressure reduction

Amlodipine blocks calcium channels in vascular smooth muscle to cause direct vasodilation, while benazepril inhibits ACE to reduce angiotensin II production — attacking hypertension through two independent and additive pathways simultaneously.

ACE inhibitor kidney protection

Benazepril reduces intraglomerular pressure and protein leakage, providing kidney-protective benefits beyond blood pressure control — particularly valuable for people with high blood pressure with diabetes or early chronic kidney disease.

Single-tablet adherence benefit

Combining a CCB and ACE inhibitor in one pill reduces daily pill count and the risk of forgetting individual medications — improving long-term adherence in people who require dual therapy to achieve blood pressure targets.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

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