Leucovorin

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Available nationwide

What is leucovorin?

Leucovorin is a form of folinic acid — an active form of the B vitamin folate — used in medicine primarily to protect normal cells from the toxic effects of methotrexate chemotherapy (a process called leucovorin rescue), and to enhance the anti-cancer effectiveness of 5-fluorouracil in colorectal cancer treatment. It's also co-administered with pyrimethamine (Daraprim) to prevent the folate deficiency and bone marrow suppression that drug can cause. Unlike folic acid supplements, leucovorin bypasses the enzyme that methotrexate blocks, allowing normal cells to maintain folate metabolism even during high-dose methotrexate therapy.

Methotrexate rescue

Leucovorin bypasses the dihydrofolate reductase enzyme that methotrexate inhibits, restoring folate-dependent metabolic pathways in normal tissues — protecting bone marrow, GI mucosa, and other rapidly dividing healthy cells from methotrexate toxicity after high-dose chemotherapy.

5-FU chemotherapy enhancement

Stabilizes the bond between 5-fluorouracil and thymidylate synthase, the enzyme 5-FU targets in cancer cells — increasing the duration and potency of 5-FU's DNA-blocking activity and improving its effectiveness in colorectal cancer treatment.

Folate pathway bypass

As a pre-reduced form of folate, leucovorin can be directly used by cells without enzymatic activation — allowing normal folate metabolism to continue in situations where key folate enzymes are blocked by antifolate drugs or genetic defects.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

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