Hyzaar

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Compare prices at 50K+ pharmacies nationwide

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Hyzaar?

Hyzaar is a combination blood pressure medication containing losartan, an angiotensin II receptor blocker (ARB), and hydrochlorothiazide (HCTZ), a thiazide diuretic. Together, they lower blood pressure through two complementary mechanisms — losartan blocks vasoconstriction from angiotensin II while HCTZ reduces blood volume through increased kidney excretion of salt and water. The combination also helps counteract some of each drug's side effects: HCTZ tends to raise potassium loss, while losartan tends to retain it. It's taken once daily and is appropriate for people who need dual therapy to achieve blood pressure control.

Dual angiotensin blockade and diuresis

Losartan blocks AT1 receptors to prevent angiotensin II-driven vasoconstriction, while hydrochlorothiazide reduces circulating blood volume by inhibiting sodium reabsorption in the kidney — attacking high blood pressure through two independent and additive mechanisms.

Complementary electrolyte balance

HCTZ causes potassium loss, while Losartan's aldosterone-blocking effect tends to conserve potassium — the two effects partially offset each other, producing a more balanced electrolyte profile than HCTZ used alone.

Stroke risk reduction in hypertension with LVH

Hyzaar has specific clinical trial evidence for reducing stroke risk in people with high blood pressure with left ventricular hypertrophy — a cardiovascular benefit that extends beyond blood pressure lowering alone.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

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