Capsaicin

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What is capsaicin?

Capzasin is a topical analgesic containing capsaicin—the active component of chili peppers—used to relieve localized pain from conditions including arthritis, neuropathy, and musculoskeletal pain. It works by depleting substance P, a neurotransmitter in sensory nerve fibers responsible for transmitting pain signals. With repeated use, the nerve endings in the treated area become temporarily desensitized, reducing pain perception over time. It must be applied consistently several times daily for several weeks before the full pain-relieving effect builds—and it typically causes a burning or stinging sensation initially that diminishes with continued use.

Substance P depletion

Capsaicin activates TRPV1 receptors on sensory nerve endings, initially triggering the release of substance P and causing the familiar burning sensation — with repeated use, substance P stores are depleted and the nerve becomes desensitized to pain signals.

Progressive desensitization

The pain-relieving effect builds over 1 to 2 weeks of consistent use as sensory nerve fibers become temporarily inactivated — people must persist through the initial burning phase to reach the therapeutic desensitized state.

Non-opioid localized pain relief

Provides meaningful pain reduction for arthritis, diabetic neuropathy, and post-herpetic neuralgia through a non-opioid, non-systemic mechanism — useful for people who want to minimize systemic pain medication or who need targeted relief for a specific joint or area.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

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