Estrace

Brand for Estradiol

Without insurance

With insurance

Compare prices at 50K+ pharmacies nationwide

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Estrace?

Estrace is an oral estrogen medication containing estradiol—the primary form of estrogen produced by the ovaries—used to treat menopausal symptoms including hot flashes, night sweats, vaginal dryness, and mood changes. It's also used in hormone therapy for transgender women and in cases of premature ovarian insufficiency. Taken as a daily tablet, it restores estrogen levels that decline during and after menopause. For women with a uterus, a progestin is typically prescribed alongside it to protect the uterine lining from overstimulation.

Estrogen receptor activation

Binds to estrogen receptors throughout the body—in the brain, bones, cardiovascular system, and genitourinary tract—restoring the hormonal signaling that declines with menopause and drives its wide range of symptoms.

Hot flash and vasomotor relief

Directly addresses the hypothalamic thermoregulatory instability caused by estrogen deficiency, reducing the frequency and severity of hot flashes and night sweats that disrupt daily life and sleep.

Genitourinary and bone health

Restores vaginal tissue health, reduces urinary symptoms associated with genitourinary syndrome of menopause, and helps maintain bone density—protecting against the accelerated bone loss that follows estrogen decline after menopause.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

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