Doxepin

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Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is doxepin?

Doxepin is a tricyclic antidepressant that, at higher doses, treats depression and anxiety, and at very low doses is FDA-approved specifically for insomnia characterized by difficulty staying asleep. Its sleep-promoting effects come from its potent antihistamine activity, which produces sedation without the dependency risks of traditional sleep medications. At the low doses used for insomnia (3 to 6 mg), it's one of the few medications approved for sleep maintenance insomnia — the frustrating pattern of waking up in the middle of the night or too early in the morning.

Histamine H1 receptor blockade

At low doses, doxepin blocks H1 histamine receptors in the brain, which produces sedation and extends sleep duration without the tolerance, dependence, or next-day impairment of many other sleep medications.

Sleep maintenance focus

Uniquely approved for sleep maintenance insomnia (difficulty staying asleep), rather than just sleep onset — addressing the middle-of-night and early morning awakening patterns that many people struggle with most.

Non-controlled sleep option

Not a controlled substance at any dose, meaning it can be prescribed more freely and used longer-term without the regulatory restrictions and dependency concerns that apply to benzodiazepines and Z-drugs.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

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General Medicine provides convenient care for all of your of health needs, including common and chronic conditions, specialist consultations, and preventative care. We make it easy to get the care you need—whether it's getting the right prescriptions, labs or imaging, or connecting you with the right specialists or in-person providers—ensuring your healthcare experience is seamless and stress-free.

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