General MedicineGeneral Medicine
Cyproheptadine

Cyproheptadine

Without insurance

With insurance

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is cyproheptadine?

Cyproheptadine is a first-generation antihistamine with a broader range of uses than most allergy medications. While it treats allergic symptoms like itching, hives, and runny nose, it's also widely used off-label to stimulate appetite in people with poor appetite or unintentional weight loss, to prevent migraines, and to manage serotonin syndrome. Its appetite-stimulating effect comes from its blockade of serotonin receptors involved in satiety signaling. It causes significant sedation, which can be a side effect or a therapeutic benefit depending on the person's needs.

Histamine and serotonin blockade

Blocks both H1 histamine receptors and serotonin receptors, giving it a broader pharmacological profile than standard antihistamines — accounting for its effectiveness across allergy, appetite, and migraine applications.

Appetite stimulation

By blocking serotonin receptors involved in satiety, cyproheptadine reduces the brain signals that suppress hunger — making it a useful off-label option for people with poor appetite, low weight, or failure to thrive.

Migraine prevention

Used at low daily doses to reduce migraine frequency, particularly in children and teens, where it has a well-established off-label track record for prophylactic headache management.

Virtual visit with clinician

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

5 out of 5 stars on Trustpilot

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

5 out of 5 stars on Trustpilot

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

5 out of 5 stars on Trustpilot

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

5 out of 5 stars on Trustpilot

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

5 out of 5 stars on Trustpilot

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

5 out of 5 stars on Trustpilot

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

5 out of 5 stars on Trustpilot

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