Auvelity

Brand for bupropion

Without insurance

With insurance

Compare prices at 50K+ pharmacies nationwide

Most insurance accepted

Board-certified clinicians

No hidden fees

Available nationwide

What is Auvelity?

Auvelity is a prescription combination medication approved for major depressive disorder in adults, pairing dextromethorphan (DXM) — an NMDA glutamate receptor antagonist — with bupropion, which both enhances DXM's CNS activity and provides its own antidepressant effects. The combination represents a new mechanism for treating depression: targeting the glutamate system rather than solely focusing on serotonin, dopamine, or norepinephrine. Bupropion inhibits the enzyme that rapidly breaks down DXM, allowing it to reach therapeutic brain levels for antidepressant effect. Auvelity is taken twice daily and demonstrated faster onset of action in clinical trials — with some people experiencing improvement within one week.

NMDA receptor antagonism

Dextromethorphan blocks NMDA glutamate receptors in the brain, modulating excitatory neurotransmission and promoting synaptic plasticity — a depression treatment mechanism distinct from all existing monoamine-based antidepressants.

Bupropion as pharmacokinetic enhancer

Bupropion inhibits CYP2D6, the enzyme that rapidly metabolizes DXM, dramatically extending its half-life and allowing DXM to reach brain concentrations sufficient for antidepressant effect — while also contributing its own dopamine and norepinephrine reuptake inhibition.

Faster antidepressant onset

Clinical trials showed meaningful symptom improvement in some people within the first week — faster than the typical 4 to 6 week onset of standard antidepressants — which may be clinically significant for people in acute depressive episodes.

Ongoing support, always available.

Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

We stay proactive so your care stays steady — adjusting your plan as needed and keeping you informed every step of the way.

What our customers have to say

4.7 stars from 550+ reviews

Everything is upfront

Everything is upfront and exactly what they state. No hidden costs or fees. Great experience!

Leslie

I felt heard and they followed through

I felt heard and they followed through until my prior authorization was approved after it was denied. They maintained communication with me until I received my medication.

Nichelle C

Got refills quickly and affordably

I needed medication refills, and they were able to fill them quickly and affordably.

Mya Harbison

Quick and easy from booking to Zoom

Everything was quick and easy from booking the blood work to our Zoom appointment. The doctor was pleasant and attentive.

Judy S

Listened and responded right away

The physician I was paired with listened to all of my concerns and responded right away. She was thorough, and I received my medication within hours.

Camille

Prescription confirmed within 45 minutes

I’d run out of a medication while I was in the process of changing doctors. I provided some information, and my prescription was done and confirmed within 45 minutes.

Mark

Thorough history check and a prompt prior authorization

They were very thorough in checking my medical history for any possible problems with the new medication, and very prompt in handling the prior authorization with the pharmacy and the insurance carrier.

Louis

Dive deeper: get the support you need

Your health rarely comes down to just one thing. If your clinician identifies related needs during your visit, we can help address them through additional services.

Medications

We will write your prescription and send it to your pharmacy

Lab tests

See cost up front and book your lab test instantly

Dermatology

Get a specialist consult or talk to a clinician about your condition

Travel needs

Going on a big trip? Get the vaccines and medications you need

Everyday care

No waitlist, rushed visits, or hidden fees—get care fast.

Frequently asked questions

What is General Medicine?

What can General Medicine help with?

General Medicine provides convenient care for all of your of health needs, including common and chronic conditions, specialist consultations, and preventative care. We make it easy to get the care you need—whether it's getting the right prescriptions, labs or imaging, or connecting you with the right specialists or in-person providers—ensuring your healthcare experience is seamless and stress-free.

How much does General Medicine cost?

Who is the care team at General Medicine?

How do you protect my health information?