Acyclovir

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What is Acyclovir?

Acyclovir is an antiviral medication used to treat infections caused by herpes simplex virus (HSV-1 and HSV-2) and varicella-zoster virus, including genital herpes, cold sores, chickenpox, and shingles. It works by targeting a viral enzyme to block DNA replication inside infected cells, limiting the virus's ability to spread and reproduce. Acyclovir is available in oral tablets, topical cream, and intravenous formulations. The oral form is used for initial and recurrent outbreaks and for suppressive therapy; the topical cream provides mild relief for cold sores; and IV acyclovir is used for severe or systemic herpes infections.

Viral thymidine kinase activation

Acyclovir is selectively activated by herpes virus-encoded thymidine kinase inside infected cells, concentrating its antiviral effect where the virus is actively replicating while minimizing effects on uninfected tissue.

DNA polymerase chain termination

The activated form of Acyclovir is incorporated into viral DNA and acts as a chain terminator, halting the replication of viral genetic material and preventing the production of new infectious virus particles.

Multiple formulation versatility

Available as oral tablets for systemic treatment and suppression, topical cream for local cold sore relief, and IV formulation for severe or disseminated infections—providing treatment options across the full spectrum of herpes virus disease severity.

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Your care doesn’t end after your visit. Message your care team anytime to discuss side effects, ask questions about your medication, or request a refill.

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